The Substance is a 2024 body horror film co-produced, written and directed by Coralie Fargeat. The film stars Demi Moore, Margaret Qualley and Dennis Quaid. An international co-production between the United Kingdom and France, its plot follows a fading celebrity who decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself, unknowingly giving her horrifying side effects.

Host(s) Mike, David